...Inflammation Is the Result of a Multi-faceted ProcessHormonal changes are at the root of acne pathogenesis.The primary target of acne is the pilosebaceous unit of the follicle.Hormones stimulate increased production of lipids in the follicle.Inflammation probably arises from the presence of prostaglandins and cytokines that are attracted to the lipids within the follicle.Some individuals may be genetically prone to overactive inflammatory pathways, which increases their chances of having severe inflammatory acne....»
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«...The effect of androgens is to enlarge the sebaceous glands and also to increase the production of sebum. The sebum can mix with dead skin cells inside a hair follicle and forms a plug in the follicle (pore). The increase in sebum accelerates the formation of plugs in the pores, and also speeds up the multiplication of the bacteria on your skin. The plug can also rupture the follicle, and release its contents into the body of the skin itself....»
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